The machanisms of HSF1-mediated transcription

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地            点  ： 理科群3号楼A110

讲座内容：

All living cells must regulate gene expression to maintain proteostasis capacity or buffering capacity against protein misfolding, which is caused by environmental or metabolic changes. The heat shock response (HSR) is one of evolutionally conserved mechanisms of controlling proteostasis capacity, and is regulated by ancient heat shock factor (HSF) family members (HSF1-HSF4). Among them, HSF1 is a master regulator of the HSR in mammals, and its activity is tightly related with ageing, age-related neurodegenerative diseases and cancers. To understand mechanisms by which HSF1 regulates transcription and proteostasis capacity, we have recently identified components of HSF1-transcription complex and analyzed these functions. We found that HSF1 constitutively accesses to nucleosomal DNA in complex with RPA, which is involved in DNA replication and repair, and regulates basal proteostasis capacity. Stress-induced HSF1 activity and the HSR are also modulated by SSBP1, a regulator of mitochondrial DNA metabolism. Furthermore, HSF1 interacts with poly(ADP-ribose) polymerases and plays roles in maintenance of both proteostasis and genome integrity. Our findings identify mechanisms by which HSF1 maintains homeostasis of protein and DNA, and suggest that HSF1 is an integrator of both proteome and genome.

主讲人介绍：

中井彰，医学博士，日本山口大学医学系研究科生物化学与分子生物学专业教授， HSF研究领域国际知名专家之一。1987年毕业于日本鸟取大学医学部，1991年取得医学博士学位。1991年-1993年在美国西北大学从事博士后工作，而后在京都大学担任助教。2000年至今在山口大学医学部担任教授。从事真核基因的转录机制研究（HSF）20余年，发表研究论文及综述100余篇，主编及参编书籍20部。

发布时间：2016-10-19 10:58:00